Soybean‐derived peptide protects against an <i>E</i>. <i>coli</i>‐induced sepsis in cynomolgus monkeys

Autologous transplantation of GDNF-expressing mesenchymal stem cells protects against MPTP-induced damage in cynomolgus monkeys

Glial cell-derived neurotrophic factor (GDNF) has shown beneficial effects in models of Parkinson's disease. The mild results observed in the double-blind clinical trial by intraputamenal infusion of recombinant GDNF proteins warrant a search for alternative delivery methods. In this study, we investigated the function of autologous mesenchymal stem cells (MSCs) expressing GDNF (GDNF-MSCs) for ...

Splenectomy Protects against Sepsis Lethality

Peptide and Protects Against Apoptosis

The amyloidb peptide (A b ) can mediate cell attachment by binding to b 1 integrins through an arg-his-asp sequence. We show here that the a 5 b 1 integrin, a fibronectin receptor, is an efficient binder of A b , and mediates cell attachment to nonfibrillar A b . Cells engineered to express a 5 b 1 internalized and degraded more added A b 1-40 than did a 5 b 1-negative control cells. Deposition...

Diltiazem protects against functional changes in chronic cerebrovasospasm in monkeys.

Diltiazem given 48 hours before experimental subarachnoid hemorrhage protects the cerebral vasculature of monkeys against the widespread cerebrovascular spasm seen on angiography after 5-6 days and against associated neurologic defects. In vitro examination of the cerebral arteries from treated monkeys shows that compared with untreated animals, the functional changes in the vascular smooth mus...

An outbreak of salmonellosis in newly imported cynomolgus monkeys.

Serious salmonellosis occurred in groups of cynomolgus monkeys newly imported into Tsukuba Primate Center for Medical Science from the Philippines in 1985. During the quarantine period, Salmonella typhimurium (29 strains) and S. stanley (1 strain) were isolated from 30 of 130 imported monkeys. Twenty-eight of the 30 infected monkeys excreted mainly watery diarrhea, and occasionally bloody mucou...